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Experts from the University of Manitoba, Winnipeg, MB, Canada, retrospectively reviewed the instances of 5,715 sufferers with septic shock to determine the appropriateness of initial antimicrobial therapy, clinical illness site, and relevant pathogens. Results showed that inappropriate initial antimicrobial therapy happened in 20 % of patients, and the overall survival was 43.7 %. Survival after appropriate and inappropriate initial therapy was 52 % and 10.3 %, respectively. Furthermore, the reduction in survival with inappropriate preliminary therapy ranged from 2.3-fold for pneumococcal infection to 17.6-fold with primary bacteremia. Researchers conclude that initiatives to increase the regularity of appropriateness of preliminary antimicrobial therapy should be central to attempts to lessen mortality from septic shock.